OxyContin maker will stop promoting opioids to doctors

OxyContin maker will stop promoting opioids to doctors




The maker of the highly effective painkiller OxyContin mentioned it can cease advertising opioid medication to docs, bowing to a key demand of lawsuits that blame the corporate for serving to set off the present drug abuse epidemic.

OxyContin has lengthy been the world’s top-selling opioid painkiller, bringing in billions in gross sales for privately-held Purdue, which additionally sells a more moderen and longer-lasting opioid drug referred to as Hysingla.

The corporate introduced its shock reversal on Saturday. Purdue’s assertion mentioned it eradicated greater than half its gross sales employees this week and can now not ship gross sales representatives to docs’ places of work to debate opioid medication. Its remaining gross sales employees of about 200 will concentrate on different drugs.

The OxyContin tablet, a time-release model of oxycodone, was hailed as a breakthrough remedy for persistent ache when it was accepted in late 1995. It labored over 12 hours to take care of a gradual stage of oxycodone in sufferers affected by a variety of ache illnesses. However some customers rapidly found they might get a heroin-like excessive by crushing the drugs and snorting or injecting the complete dose without delay. In 2010 Purdue reformulated OxyContin to make it tougher to crush and stopped promoting the unique type of the drug.

Purdue finally acknowledged that its promotions exaggerated the drug’s security and minimized the dangers of dependancy. After federal investigations, the corporate and three executives pleaded responsible in 2007 and agreed to pay greater than $600 million for deceptive the general public in regards to the dangers of OxyContin. However the drug continued to rack up blockbuster gross sales.

Dr. Andrew Kolodny, director of opioid coverage analysis at Brandeis College and an advocate for stronger regulation of opioid drug corporations, mentioned Purdue’s determination is useful, nevertheless it will not make a serious distinction until different opioid drug corporations do the identical.

“It’s tough to advertise extra cautious prescribing to the medical neighborhood as a result of opioid producers promote opioid use,” he mentioned.

Allergan, which makes three opioid ache drugs, mentioned it has not actively marketed these medication in years, and Janssen Prescribed drugs, a unit of Johnson & Johnson, mentioned it stopped advertising the drugs in 2015. Each mentioned opioid medication make up a really small portion of their complete income. One other drugmaker, Insys, mentioned it was not capable of remark instantly, whereas Teva Pharmaceutical Industries didn’t instantly reply to a request for remark.

Kolodny mentioned that opioids are helpful for most cancers sufferers who’re affected by extreme ache, and for individuals who solely want a ache treatment for just a few days. However he mentioned the businesses have promoted them as a remedy for persistent ache, the place they’re extra dangerous and fewer useful, as a result of it is extra worthwhile.

“They’re nonetheless doing this overseas,” Kolodny added. “They’re following the identical playbook that they utilized in the USA.”

Purdue Pharma solely does enterprise within the U.S. It’s related to two different corporations, Mundipharma and Napp, that function in different international locations. It mentioned these corporations have separate management and function in keeping with native laws.

Purdue and different opioid drugmakers and pharmaceutical distributors proceed defending themselves towards a whole lot of native and state lawsuits looking for to carry the business accountable for the drug overdose epidemic. The lawsuits say drugmakers misled docs and sufferers in regards to the dangers of opioids by enlisting “entrance teams” and “key opinion leaders” who oversold the medication’ advantages and inspired overprescribing. State and native governments are looking for cash and adjustments to how the business operates, together with an finish to the usage of outdoors teams to push their medication.

Kolodny is serving as an skilled advising the courtroom in these lawsuits.

U.S. deaths linked to opioids have quadrupled since 2000 to roughly 42,000 in 2016, or about 115 lives misplaced per day. Though initially pushed by pharmaceuticals, most opioid deaths now contain illicit medication, together with heroin and fentanyl.




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